Benzodiazepines are typically metabolized by hepatic oxidation followed by hepatic glucuronidation. For patients with liver damage, alternative benzodiazepines that do not undergo hepatic oxidation include lorazepam (L), oxazepam (O), and temazepam (T); use the LOT mnemonic to remember safer benzodiazepines in patients with liver damage. Benzodiazepines are cross-tolerant with alcohol and are considered the first […]